The Horned Frogs fell to the Commodores 81-78 at the Big 12/SEC Challenge in Nashville.
The two programs have combined for just 10 losses in the 2017-18 season thus far.
The Horned Frogs won their first game as a ranked team, defeating the Wildcats 68-63.
The Horned Frogs are ranked No. 24 in this week's AP Poll.
The Horned Frogs defeated Kansas 76-66 in a defensive-minded game.
The junior is the Horned Frogs leading scorer, despite not starting a game all season.
The TCU Women's Basketball team notched their second straight victory over a ranked opponent, defeating No. 15 West Virginia 76-74.
The TCU Women's Basketball team defeated Texas Tech 93-72 on Sunday.
The junior forward scored a career-high 31 points against Hampton.
The 9-2 Horned Frogs defeated Hampton 90-68 to complete their nonconference slate.