The Broncos proved too much for the Horned Frogs, breaking down a TCU defense that went 398 minutes without allowing a goal.
TCU started the match strong, but Santa Clara recovered well and took the lead in the 24th minute with a goal from midfielder Skylar Smith.
The Broncos doubled their lead in the 39th minute when forward Julie Doyle headed home a long cross. They added another goal in the 60th minute courtesy of midfielder Maddy Gonzalez.
A bright spot for TCU was goalkeeper Emily Alvarado, who made a career-high seven saves and kept the Horned Frogs in the game in the first half.
Next up for TCU is a home match against the Butler Bulldogs, No. 23 in the United Soccer Coaches Poll. Kickoff is set for Sunday at 1 p.m.