Cincinnati only made one field goal in the last 14:39 of the game.
The senior scored a career-high 36 points to lead the Horned Frogs to victory.
The junior hit the 30-point mark for the second time this month after scoring 34 against Texas on March 9.
The Horned Frogs exploded in the fourth quarter to advance to the quarterfinals of the WNIT.
All 11 players on TCU's rosters played and scored in the blowout victory.
In a game that "felt like it was an NCAA tournament game" the Horned Frogs fell short in the final seconds.
Moore and Okonkwo are looking to lead TCU to the NCAA tournament for the first time in their careers.
The Horned Frogs collected 21 hits and scored their highest run total since 2012.
The head coach also provided an update on former wide receiver KaVontae Turpin.
The team's seniors combined for 48 points.